The game depicts Christof's centuries-long journey from the Dark Ages of 12th century Prague and Vienna to modern-day London and New York City in search of his humanity and his kidnapped love, the nun Anezka.
Set in White Wolf Publishing's World of Darkness, the game is based on White Wolf's role-playing game Vampire: The Masquerade and follows the adventures of Christof Romuald, a 12th-century French crusader who is killed and subsequently revived as a Vampire. Vampire: The Masquerade – Redemption is a 2000 role-playing video game developed by Nihilistic Software and released by Activision for Microsoft Windows and Mac OS.